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Plants are an essential part of our world, providing oxygen, nutrients, and numerous ecosystem services. They are also integral in addressing the most pressing global challenges such as food security, human health, environmental sustainability, and climate change. It is important to advance our understanding of how plants have evolved a variety of unique life strategies and biochemical features that distinguish them from other organisms. We are particularly interested in studying the intricate mechanisms controlling gene expression, which allow plants to optimize their growth, adaptability, and resilience in response to changing environments.

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Plant Regeneration
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What gives plants the exceptional ability to regenerate entire organs? In their natural environments, plants exhibit the capacity to regenerate tissues and organs in response to injuries. In vitro tissue culture leverages this regenerative capability through a two-step process to induce desired organs. We use these regeneration models to understand the cellular and molecular mechanisms underlying cellular reprogramming, pluripotency acquisition and tissue regeneration. Our investigations are substantiated by state-of-the-art technologies, including epigenome analysis, genome editing, local interactome analysis, and single-cell analysis.
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#Plant regeneration, #Tissue culture, #Pluripotency, #Wound sensing, #Epigenetic resetting
Genome Biology
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Gene expression is dynamically regulated through the remodeling of chromatin architecture. Chromatin architecture is determined at various levels, ranging from the chemical modifications of DNA, RNA and histone proteins to the 3D spatial rearrangement of chromatins. We are trying to understand the dynamic interplay between 3D chromatin organization, epigenetic regulation, and RNA modifications. Based on our numerous NGS datasets (BS-seq, ChIP-seq, ATAC-seq, Hi-C and multiomic single-cell seq), we aim to build an epigenome atlas and dissect epigenetic complexity using machine learning-based algorithms.
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#Epigenetics, #Chromatin modification, #3D folding, #Computational biology
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Molecular Sensing and Signaling in Plants
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Plants have evolved an array of unique signaling mechanisms to integrate cues from the surrounding environment and endogenous signals to regulate metabolism, growth, development, and survival. We have a primary interest in identifying key signal-initiating sensors and signaling crosstalk within an extensive signaling network, as well as discovering unknown transcriptional regulatory interactions. We also employ untargeted approaches to identify critical metabolite-protein interactions.
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#Plant signaling network, #Sensor protein, #Signal crosstalk, #Metabolite signaling
Plant Molecular Engineering
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Plants have the ability to produce numerous bioactive molecules that not only fulfill various functions for the plant itself (defense, ecosystem communication, etc.), but also hold significant importance for humanity (food, medicines, pesticides, fragrances, etc.). We strive to engineer plants at the levels of genome, cell type, and metabolic pathway to enhance food security, bioenergy production, sustainability, and human health. We are committed to developing new tools and techniques to innovate, expedite, and implement biotechnological applications in plant systems.
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#Genome engineering, #Metabolic engineering, #Nanotechnology, #Synthetic biology
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Technical Expertise
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Our research lies at the intersection of biology, chemistry, engineering, and synthetic biology. We offer comprehensive technical support through both our own expertise and external collaborations. Our best technical capabilities include bioinformatics, single-cell analysis, bioimaging, proteomics, nanotechnology, and plant cell and tissue culture techniques.